Summary

One of Leonard's fellow scientists at Caltech, Leslie is the one woman who has had any physical relationship with Leonard on the series. Quick witted, Leslie seems to be liked by everyone, though it would seem that Penny is a little jealous of her because of her relationship with Leonard.

Leslie has only appeared in two episodes, but what is most interesting about her is the fact that she is played by Sara Gilbert. On the sitcom Roseanne, Sara's character and Johnny Galecki's character were married.